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Causes of fatigue that can be treated by natural medicine are poor digestion & absorption e.g. in Crohn's disease, coeliac disease), bowel flora imbalance, infections, adrenal exhaustion, blood sugar & hormonal imbalance.
Suffering from chronic fatigue, headaches, constipation, gallbladder disease/gallstones, acersion to fats, terrible hangovers, etc. These are common symptoms of what is known in natural medicine as a sluggish liver.