Detoxification

  • Arsenic in Bottled Water

    Your bottled water has likely contained arsenic. In August 2019 all bottled water brands produced by Irish company Celtic Pure have been recalled by the Food Safety Authority of Ireland due to the presence of the arsenic. Why take the risk in buying bottled water when you can filter tap water?

  •  

    Your Practitioner

    Ear acupuncture involves the stimulation of definite points on the ear to normalise the bodily function. These points are believed to correspond with specific organs, emotions or sensory feelings. Ear acupuncture increases serotonin and endorphins and is very relaxing.

    Evidence exists for the use of ear acupuncture in drug and alcohol detoxification, smoking cessation, weight loss, stress anxiety, depression and musculoskeletal disorders.

    For further details contact Carina This email address is being protected from spambots. You need JavaScript enabled to view it.

    Read more Traditional Chinese Medicine

  • ear acupuncture theory

    The use of acupuncture for the treatment of drug and alcohol dependency (Acudetox) is a recent development in the history of Traditional Chinese Medicine.

  • carina head shot

    Qualified in acupuncture, naturopathy and homeopathy, I specialise in detoxification, diet, weight loss, performance boost, fertility, pregnancy, parenting and healthy ageing

  • Diagnose, Assess & Treat Physical, Mental & Emotional Disorders

  • Carahealth Eco Water Filter

    Eco gravity water filters provide environmentally friendly, low plastic & a low carbon solution to clean, safe & plastic Free drinking water with no instillation costs, removing 99.99% of contaminants including:

    Waterborne Disease - Cryptosporidium & e-coli are parasites typically above 2μm (microns) & are removed by the ceramic outer shell (1μm).

    Chemicals - Chlorine, Fluoride, Pesticides, THM’s, Phenols, Petrol Chemicals, etc

    Suspended Solids - Microplastics, Lead, Copper, Mercury, Cadmium, Chromium Fluoride, Aluminium, Nickel, etc.

  • Environmentally Friendly, Clean, Healthy & Plastic Free Water

  • Image

    Eyesight is precious, our eyes provide a way for us to see the world and for the world to see us. One of the greatest problems we are faced with as an aging population is eye disease.

  • Female

  • Natural Fertility & Pregnancy series of consultations, aims to expelthe body of toxins increasing circulation to the uterus while tonifying the uterine tissues & prepare the uterus for birth.

    Practitioner

    When preparing for conception it is important to create a healthy body environment to ensure a healthy pregnancy and child.

    The Alternative Medicine Fertility plan supports the liver's natural detoxification processes to expel the body of toxins & prepare the uterus for birth. By encouraging the liver to cleanse the body of toxins and excess hormones & supporting the uterus to cleanse itself of old stagnant blood, increasing circulation to the uterus while tonifying the uterine tissues.

    Why do you need to conduct a fertility cleanse?

    Bioaccumulation is a term used to describe the accumulation of fat soluble toxins including heavy metals such as lead, mercury & cadmium, endocrine disrupting chemicals (EDCs) such as PCBs, phthalates and bisphenol A, pesticides such as DDT & drugs in the body's fat cells. Many recent studies have confirmed widespread exposure and bioaccumulation of chemical toxicants and the negative health impacts on the development of the foetus and child.

    Bioaccumulation has a negative effect on male fertility

    Endocrine disrupting chemicals (EDCs such bisphenol A, phthalates, polychlorinated biphenyls, can interfere with normal hormonal balance and can adversely effect the male reproductive system leading to low sperm count and poor sperm motility and sperm quality. 3 4

    The importance of vitamins & minerals to enhance fertility

    Nutrition plays a big role in having healthy fertility and experiencing a healthy pregnancy. Nutritional deficiencies have been linked to hormonal imbalance, irregular ovulation and lowered egg health, low sperm count and low libido. Therefore it is important to address any nutritional deficiencies and ensure adequate intake of all these essential vitamins and minerals to enhance chances of conception.

    The alternative medicine fertility plan is designed to;

    • Regulate ovulation and menstruation to promote fertility.
    • Use traditional aphrodisiac to promote libido
    • Support adrenal function and improve energy
    • Supporting liver phase I and Phase II detox processes to assist the body in eliminating endocrine disrupting and mutagenic chemicals
    • Tonify the uterine muscle
    • Cleansing the womb of any stagnant blood in preparation for conception.
    • Ensure you and your partner have all the nutrients required to promote fertility

    Natural ​Fertility & Pregnancy series of consultations, what to expect?

    The initial consultation with the prospective mother aimed to specifically to boost libido and enhance Female Fertility and involves conducting a full length case history to ascertain current health level, along with a dietary assessment. If you have a presenting health condition it is better to book an individual consultation prior to commencing this course. This consultation will aim to make recommendations for a cleansing gentle detox diet to support Phase 1 & II Liver Detoxification Pathways and clean the uterus and testes of fat soluble toxins including heavy metals such as lead, mercury & cadmium, endocrine disrupting chemicals (EDCs) such as PCBs, phthalates and bisphenol A, pesticides such as DDT & drugs in the body's fat cells including the uterus. This is essentially a Liver cleanse, Heavy Metal/Plastic Detox diet.


    The second consultation

    This is an individual consultation with the prospective father aimed to specifically to enhance Male Fertility.


    The third consultation

    This is a joint consultation with the prospective mother and father to discuss essential vitamins required to enhance fertility and increases chances of conception make a healthy baby and to make recommendations in regard to nutritional deficiencies. Specifically we will discuss food sources of folic acid, iron, B12, calcium, magnesium, the correct balance of omega 3: omega 6 all vital for foetal development.

    For further details contact Carina Harkin BHSc.Acu.BHSc.Nat.BHSc.Hom. Cert IV TAE. This email address is being protected from spambots. You need JavaScript enabled to view it.

     1 Kim S et al., Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2years of age- CHECK cohort study.Sci Total Environ. 2018 May 15;624:377-384.

    2 Niladri Basu et al., Mercury Levels in Pregnant Women, Children, and Seafood from Mexico City, Environ Res. 2014 Nov; 135: 63–69.

    3 Hueiwang Anna Jeng1,Exposure to Endocrine Disrupting Chemicals and Male Reproductive Health, Front Public Health. 2014; 2: 55

    4 Chao Wang et al., The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis, Sci Rep. 2016; 6

  • Image

    Five element theory is the foundation of Chinese disciplines such as feng shui, martial arts & the I Ching (The Book of Changes, a text also Universal in its understanding & representation of the dynamic balance of opposites & the processes of unfolding events & change).

  • Traditional indications

    In Traditional Chinese Medicine Poria is known as Fu Ling茯苓 (1) and considered on of the premier Yin tonic herbs. Fu Ling is said to be neutral and bland and to enters the Lung, Liver and Heart channels to dry Dampness and tonify the Heart and Spleen to treat poor appetite, loose stools, palpations, insomnia, amnesia, oedema, eliminate phlegm, promote urination and dizziness. Fu Ling calms Shen and soothes the heart and mind and tonifies Yin. (2)

    Pharmacognosy

    Shi Quan Da Bu Tang is traditionally used to tonify the Blood and Qi to treat anaemia, anorexia, extreme exhaustion, fatigue, kidney and spleen insufficiency and general weakness, particularly after illness and after chemotherapy. It has been found to potentiate (make it work better) chemotherapy and radiotherapy and inhibit malignant recurrences, prolong survival and prevent and ameliorate adverse toxicities in cancer treatment. (3) In Japanese herbal medicine (Kampo) the formula is known Juzen Taiho To and has been shown to increase expression of heavy metal chelating metallothioneins (MTs). (4) Shi Quan Da Bu Tang also increases transcription factor Nrf2 to support phase II detoxification thus regulate the body's detoxification and antioxidant system. (5) Alfalfa Medicago sativa contains heavy metal chelating plant metallothiones. (6)

    Heavy Metal and Microplastics Detox

    Heavy Metal & Plastic Detox

    1. Nong S. Poria 2019.
    2. Healing WRIo. Poria (Fu Ling) 2019.
    3. Chang I-M. Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Application. Evidence-based Complementary and Alternative Medicine. 2006;3(3):393-4.
    4. Anjiki N, Hoshino R, Ohnishi Y, Hioki K, Irie Y, Ishige A, et al. A kampo formula Juzen-taiho-to induces expression of metallothioneins in mice. 2005;19(10):915-7.
    5. Wu Q, Zhang D, Tao N, Zhu QN, Jin T, Shi JS, et al. Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs. Am J Chin Med. 2014;42(1):207-21.
    6. Robinson NJ, Tommey AM, Kuske C, Jackson PJ. Plant metallothioneins. The Biochemical journal. 1993;295 ( Pt 1)(Pt 1):1-10.

  • Xiao Yao San Tonic

  • tea bags

    Tea contains a number of bioactive chemicals that contribute to health, however, can contain a number of hazardous substances including plastic that present public health risk.

  • Healthy Aging & Longevity series of consultations, involves a polyphenol rich ketosis diet. A ketosis diet is in itself anti aging. A healthy weight is paramount to healthy aging. If weight is an issue then weight must be addressed and will be with this plan. If weight is not an issue, a ketosis diet does not have to be a weight loss diet and can be adapted

    Practitioner

    Healthy Aging & Longevity consultations, what to expect?

    The initial consultation will ascertain what you eat and make recommendations for a ketosis diet that suits you. This will flatline insulin levels and also aim to maximising polyphenol antioxidant intake.


    The second consultation will ensure firstly, that you have achieved a state of ketosis and secondly to address any issues you have surrounding the dietary recommendations and to add more recipes.


    The third consultation will assist you in moving from phase 1 (short-term) into phase 2 (long-term) of the diet. Phase 2 is the keto diet for health and longevity, mimics fasting and is life extending.

    Healthy Aging Effects of a Keto Diet
    Lowers cholesterol: Lowers LDL & triglyceride levels and raises HDL (good cholesterol).(1)

    Induce Rapid Weight Loss: Reduces body weight and body mass index.(1)

    Lowers Blood Sugar: Studies show a ketosis diet can eliminate type 2 diabetes.(2, 3)

    Enhances physical and cognitive performance: Ketone bodies are the most energy-efficient fuel and yield more ATP.(4)

    Suppresses Appetite: High fats diets increase satiety.(5)

    Starve Cancer Cells: Cancer cells need glucose for fuel. Only healthy cells can live on ketones. Studies indicate a ketosis diet is an adjunct therapeutic aid in cancer.(6, 7)

    Treats neurodegenerative disease: Ketosis is neuroprotective and neuroregenerative(8) & therapeutic treatment in traumatic head injury, neurological disease (9)including Parkinson’s, Alzheimer's(10)& epilepsy,(11)

    Extends Life: The benefits of Calorie restriction/Keto diet are scientific fact. A Ketosis diet simulates the Calorie Restrictive Diet(12)that scientists have touted for the main reason behind Okinawan longevity.Like CR, Ketosis also activates telomerase the anti-aging enzyme. Calorie restriction increases telomerase activity and enhances autophagy (breakdown of dead cells).(13)CR improves how cells respond to stress, how they break down (autophagy), induces apoptosis (programmed cell death ie in cancer cells), and alters hormonal balance. Autophagy in particular, is quality control inside cells. It is essential for the maintenance of cellular homeostasis and for the orchestration of an efficient cellular response to stress. Autophagic activity declines with age, and this contributes to the aging process.(14)

    People who may benefit from the Vitality, Longevity and Healthy Aging plan include those who want to:

    • Slow & reverse the effects of aging.
    • Age healthily
    • Manage your weight more effectively
    • Increase muscle tone and fitness
    • Increase your energy, stamina & strength
    • Support the nutrition and health of your body
    • Decrease incidence of age-related disease
    • Look healthier & improve your quality of life

    Specifically the Life Extension plan;

    • Increases expression of the Sir 2 gene, causing an increase in Telomerase, an enzyme allowing dividing cells to replace lost DNA, thus allowing unbounded division (ie. ageless cell)
    • Increases Telomerase activity
    • Lowers Homocysteine, a naturally occurring protein of which, at high levels, is associated with age related disease
    • Maximises dietary polyphenol antioxidants to prevent free radical damage
    • Improves insulin resistance
    • Improves mitochondrial function
    • Strengthens connective tissue
    • Increases digestion, absorption, assimilation & elimination
    • Improves cognitive function
    • Tonifies the adrenal glands to increase DHEA (a precursor hormone) levels to youthful levels
    • Tonifies the Vital Force
    • Replaces nutritional deficiencies
    • Flatlines insulin levels
    • To reduce cancer risks, the plan addresses the following causes of cancer;

    The pathogenesis of cancer is as follows;

    • Overexpression of Tyrosine Kinase Receptor and resultant deficiency in apoptosis (15)
    • Overexpression of Cox (16)
    • Over expression IL6 (17)
    • Overexpression of TNF alpha (18)
    • Increases in ILGF (19)

    Hundreds of bioactive compounds have been identified as potential modifiers of cancer, several of which are active ingredients in herbs (20)

    • Inhibits the inflammatory mediator Cox(21, 22)
    • Inhibits RTK, the enzyme responsible for tumour formation (20, 23)
    • Lower inflammatory mediators IL6 (24, 25)
    • Lowers insulin like growth factor (ILGF) (26, 27)
    • Inhibit inflammatory mediator TNF alpha (28, 29)
    • Induces Apoptosis programmed cell death (30)
    • Lowers C reactive protein (CRP) (22)
    • Inhibits betaglucuronidase (31) & aromatase, (32) enzymes associated with hormone dependent cancers.
    • Is phytoestrogen rich. Phytoestrogen consumption is associated with a significant reduction in breast, prostate and other cancer risk. (33-35)

    You will receive an e-prescription including dietary, lifestyle, supplement and herbal medicine advice.

    When a herb is described as anti-aging they have anti-oxidant, anti-aging, anti-fatigue and anti-inflammatory effects. Anti-aging herbs tonify the nervous system and endocrine system. Anti-aging herbs tonify the cardiovascular system by lowering cholesterol, widening coronary arteries and boosting blood flow to the heart. Anti-aging herbs protect the liver, tone up the main internal organs, settle nerves, improve eyesight and reduce blood sugar levels to prevent diabetes. Rich in antioxidants anti-aging herbs boost the immune system, slow down the process of cellular aging. Anti-aging herbs nourishe vitality, reduces excess heat, detoxify the body, calm the mind and improve mental agility. 

    Your practitioner

    Carina Harkin BHSc.Acu.BHSc.Nat.BHSc.Hom. Cert IV TAE.
    This email address is being protected from spambots. You need JavaScript enabled to view it.

     

    1.Dashti HM, Mathew TC, Hussein T, Asfar SK, Behbahani A, Khoursheed MA, et al. Long-term effects of a ketogenic diet in obese patients. Experimental and clinical cardiology. 2004;9(3):200-5.

    2.Westman EC, Tondt J, Maguire E, Yancy WS, Jr. Implementing a low-carbohydrate, ketogenic diet to manage type 2 diabetes mellitus. Expert review of endocrinology & metabolism. 2018;13(5):263-72.

    3.Yancy WS, Jr., Foy M, Chalecki AM, Vernon MC, Westman EC. A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutrition & metabolism. 2005;2:34-.

    4.Murray AJ, Knight NS, Cole MA, Cochlin LE, Carter E, Tchabanenko K, et al. Novel ketone diet enhances physical and cognitive performance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016;30(12):4021-32.

    5.Gibson AA, Seimon RV, Lee CMY, Ayre J, Franklin J, Markovic TP, et al. Do ketogenic diets really suppress appetite? A systematic review and meta-analysis. 2015;16(1):64-76.

    6.Klement RJ. Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation. Medical oncology (Northwood, London, England). 2017;34(8):132.

    7.Morscher RJ, Aminzadeh-Gohari S, Feichtinger RG, Mayr JA, Lang R, Neureiter D, et al. Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model. PLOS ONE. 2015;10(6):e0129802.

    8.Shaafi S, Mahmoudi J, Pashapour A, Farhoudi M, Sadigh-Eteghad S, Akbari H. Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages. Advanced pharmaceutical bulletin. 2014;4(Suppl 2):479-81.

    9.Gano LB, Patel M, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. Journal of lipid research. 2014;55(11):2211-28.

    10.Włodarek D. Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease). . Nutrients. 2019;11(169).

    11.Agarwal N, Arkilo D, Farooq O, Gillogly C, Kavak KS, Weinstock A. Ketogenic diet: Predictors of seizure control. SAGE open medicine. 2017;5:2050312117712887-.

    12.Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain research reviews. 2009;59(2):293-315.

    13.Wang B-H, Hou Q, Lu Y-Q, Jia M-M, Qiu T, Wang X-H, et al. Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures. Brain Research. 2018;1678:106-15.

    14.Veech RL, Bradshaw PC, Clarke K, Curtis W, Pawlosky R, King MT. Ketone bodies mimic the life span extending properties of caloric restriction. 2017;69(5):305-14.

    15.Paul MK, Mukhopadhyay AK. Tyrosine kinase - Role and significance in Cancer. International journal of medical sciences. 2004;1(2):101-15.

    16.Mazhar D, Gillmore R, Waxman J. COX and cancer. QJM: An International Journal of Medicine. 2005;98(10):711-8.

    17.Kumari N, Dwarakanath BS, Das A, Bhatt AN. Role of interleukin-6 in cancer progression and therapeutic resistance. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016;37(9):11553-72.

    18.Wang X, Lin Y. Tumor necrosis factor and cancer, buddies or foes? Acta pharmacologica Sinica. 2008;29(11):1275-88.

    19.Kaaks R. Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. Novartis Foundation symposium. 2004;262:247-60; discussion 60-68.

    20.Kaefer CM, Milner JA. The role of herbs and spices in cancer prevention. The Journal of nutritional biochemistry. 2008;19(6):347-61.

    21.Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. Current oncology (Toronto, Ont). 2006;13(3):99-107.

    22.Ghasemian M, Owlia S, Owlia MB. Review of Anti-Inflammatory Herbal Medicines. Advances in pharmacological sciences. 2016;2016:9130979-.

    23.Teillet F, Boumendjel A, Boutonnat J, Ronot X. Flavonoids as RTK inhibitors and potential anticancer agents. Medicinal research reviews. 2008;28(5):715-45.

    24.Chun JY, Tummala R, Nadiminty N, Lou W, Liu C, Yang J, et al. Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth. Genes & cancer. 2010;1(8):868-76.

    25.Hussan F, Mansor AS, Hassan SN, Tengku Nor Effendy Kamaruddin TNT, Budin SB, Othman F. Anti-Inflammatory Property of Plantago major Leaf Extract Reduces the Inflammatory Reaction in Experimental Acetaminophen-Induced Liver Injury. Evidence-based complementary and alternative medicine : eCAM. 2015;2015:347861-.

    26.Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, et al. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging cell. 2014;13(4):769-71.

    27.Singh P, Bast F. Screening of multi-targeted natural compounds for receptor tyrosine kinases inhibitors and biological evaluation on cancer cell lines, in silico and in vitro. Medical oncology (Northwood, London, England). 2015;32(9):233.

    28.Aggarwal BB, Gupta SC, Sung B. Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. British journal of pharmacology. 2013;169(8):1672-92.

    29.Ren Y, Qiao W, Fu D, Han Z, Liu W, Ye W, et al. Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis. Journal of immunology research. 2017;2017:7424307-.

    30.Safarzadeh E, Sandoghchian Shotorbani S, Baradaran B. Herbal medicine as inducers of apoptosis in cancer treatment. Advanced pharmaceutical bulletin. 2014;4(Suppl 1):421-7.

    31.Subramanya SB, Venkataraman B, Meeran MFN, Goyal SN, Patil CR, Ojha S. Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury. International journal of molecular sciences. 2018;19(12):3776.

    32.Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD. Natural products as aromatase inhibitors. Anti-cancer agents in medicinal chemistry. 2008;8(6):646-82.

    33.Velentzis LS, Woodside JV, Cantwell MM, Leathem AJ, Keshtgar MR. Do phytoestrogens reduce the risk of breast cancer and breast cancer recurrence? What clinicians need to know. European journal of cancer (Oxford, England : 1990). 2008;44(13):1799-806.

    34.Cotterchio M, Boucher BA, Manno M, Gallinger S, Okey A, Harper P. Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. The Journal of nutrition. 2006;136(12):3046-53.

    35.Ziaei S, Halaby R. Dietary Isoflavones and Breast Cancer Risk. Medicines (Basel, Switzerland). 2017;4(2):18.

    to be a diet for life. If you don't need to lose weight you simply add keto snacks.

  • Heavy Metal & Microplastics Detoxification consultations, combine scientifically supported intermittent fasting with chelation therapy & liver herbs to support phase 1 & 2 detoxification pathways.

    Practitioner

    Places you on a short term Therapeutic Fast (CR). Toxins are called persistent organic pollutants (POP) and are detected in high concentrations in blood samples of the general population.

    (1)POPs are also called Persistent Toxic Substances (PTS).(2) In the liver, Phase I & II detoxification pathways transform fat soluble toxins into water-soluble for excretion in the urine, bile and sweat. Vitamins, minerals & herbal medicines support this process. Therapeutic Fasting increases phase II conjugation detoxification in the liver. (3)

    Applies mitigation and remediation strategies to limit the amount of ingested chemicals in air, water and food.
    Prescribes herbs containing plant metallothioneins (MTs)  (4, 5) and phytochelatins (PCs)  (6)  to chelate heavy metals.
    Prescribes herbal medicines to inhibit Phase 1 & induce II detoxification to eliminate plastic toxins BPA/Phthalates and dioxins/furans along with other POP toxins.

    Increases elimination of POP toxins via the other eliminatory organs, bowel, skin, lungs & kidneys using herbal alteratives, depuratives, circulatory stimulants, cholagogues and diuretics.

    Weans you back into a diet for life consisting of foods rich in the active constituent compounds and vitamins, nutrients & antioxidants required for detoxification pathways.  (7)

    Heavy Metals & Microplastics Detox series of  consultations, what to  expect?

    The initial consultation will place you on a Therapeutic Fast to restrict intake of toxins whilst supporting Phase I & II detoxification processes. Herbal & nutritional chelation agents are prescribed to chelate heavy metals and remove POPs toxins including plastics.

    The second consultation will ensure firstly, that you have achieved a state of Therapeutic Fasting and secondly to address any issues you have surrounding the dietary recommendations.

    The third consultation will assist you in moving from the Therapeutic Fast to a suitable long-term diet to support detoxification processes to promote health and longevity.

    Why excess toxins damage health

    If not adequately supported or in the case of excessive POPs, Phase I is induced (sped up) producing high levels of damaging free radicals. If these reactive molecules are not metabolised by Phase II conjugation damage to proteins, RNA, & DNA occurs causing genetic mutation. Disruption of Phase I can damage proteins, RNA, and DNA within the cell and is seen as an important factor in the pathogenesis of cancer. The treatment principle in plastic detoxification is to inhibit Phase I P450 (modification) and to induce Phase II detoxification (conjugation).

    Heavy metals

    Heavy metals such as cadmium, lead and mercury are common air pollutants resulting from various industrial activities.Heavy metal pollution is one of the major concerns of the century with sources being both anthropogenic (human-made) and naturogenic (from nature) with the health effects well documented.  (8)  The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. These metals have been extensively studied and their effects on human health regularly reviewed by international bodies such as the WHO.  (9)  Almost all heavy metals are serious toxicants as carcinogens. (10)  There are different sources for heavy metals in the environment. These sources can be both of natural or anthropogenic origin (chiefly of environmental pollution and pollutants).

    Plastics

    Tap Water

    8 million tons of plastic enters the oceans each year. Microplastics are ubiquitous in marine waters, from deep ocean sediments to polar icecaps. (11) Billions of people are drinking water contaminated by plastic particles with 83% of samples found to be polluted. The average number of fibres found in each 500ml of tap water sample ranging from 4.8 in the US to 1.9 in Europe.  (12, 13)  In Germany plastic fibres & fragments were found in all 24 beer brands tested, as well as honey & sugar. This study concluded average person ingests 5,800 particles of plastic per year from beer, salt & tap water, with largest contribution coming from tap water (88%).  (12)  An Irish study (June 2017) found microplastic contamination in a handful of tap water & well samples.  (14)

    Bottled Water

    The Orb study tested 259 bottled water brands from 19 locations in 9 countries across 11 different brands were found to contain on average 325 plastic pieces for every litre of water.  (15)  Plastic fibres in bottled water brands are twice as high as those found in tap water.PETE (recycling code 1) does not contain bisphenol A (BPA)/Phthalates but studies find antimony (toxic phthalate 'plasticiser' used to make plastics flexible), leaches from PET bottles placed in heat for prolonged periods.  (16)

    9 different plastics found in all human stools tested posing a threat to Public Health.  (17-19)

    Most plastic products release oestrogenic otherwise known as Endocrine Disrupting Chemicals (EDCs) which have a variety of negative health effects. (20)  EDCS include organochlorine pesticides, poly-chlorinated biphenyls, BPA, phthalates, dioxins & furans.  (21)

    EDC diseases & disorders

    EDC diseases & disorders include female & male infertility, (22) low sperm count, genital malformations, intersex variation IV, sharp increase in gender dysphoria, transgender & gender neutral (LGBTQI existed pre-industrial revolution), precocious puberty in young girls (risk factor for breast cancer), adverse pregnancy outcomes such as premature birth/low birth weight.

    Neurobehavioral disorders include cognitive, motor & sensory deficits, neurological impairments (NIs) including neuropathies, neurodevelopmental disorders) autism & attention deficit hyperactivity disorder (ADHD), neurodegenerative diseases including Alzheimer's disease, Parkinson's disease & amyotrophic lateral sclerosis (ALS). Exposure associated with persistent organic pollutants (POPs), plastic exudates BPA & phthalate.  (23)

    Other health effects include hormone dependent tumours including breast, endometrial, ovarian, prostate, testicular and thyroid, metabolic disorders including Polycystic Ovary Syndrome (PCOS), Metabolic syndrome (evidence shows EDCs may contribute to the obesity pandemic evolution & metabolic disorders including Type 2 Diabetes (T2D)  (24)  and atopic disorders such as. allergies, asthma & atopic dermatitis.  (25)

    Detoxification is not Quackery it is called Biotransformation

    Research into human biotransformation and elimination systems continues to evolve. In medical terms promotion of toxicity is called bioaccumulation and detoxification is called Biotransformation.Bioaccumulation is a term used to describe the accumulation of persistent organic pollutants (POPs) (1) also known as persistent toxic substances (PTSs)  (2)  which are detected at high levels in blood and urine samples taken for the National Health & Nutrition Examination Survey (NHANES) conducted annually in US by CDC. POPs include Serum dioxins, furans & PCB and urinary phthalates and BPA. (26)

    Heavy Metal Biotransformation

    Heavy metal bioaccumulation inhibits Phase I cytochrome P450 (CYP) enzyme system.  (27, 28)  Disruption of CYP can damage proteins, RNA, and DNA within the cell and is seen as an important factor in the pathogenesis of cancer. Arsenic for example is methylated.  (29)  The treatment principle in heavy metal bioaccumulation is use herbal extracts shown modulate P 450 in combination with plant metallothioneins (MTs) and phytochelatins (PCs) to chelate heavy metals. Certain herbs have the ability to both induce and inhibit Phase I cytochrome P450 (CYP) enzyme systems.

    Plastic Biotransformation

    Ingested plastics

    BPA & phthalates are ingested plastic toxins.

    Bisphenol A

    Accumulation of BPA induces cytochrome P450 enzyme activities. (30)

    In humans, ingested BPA is not extensively metabolised by cytochrome P 450 specifically CYP2C. (31)

    BPA is also metabolite of glutathione conjugation. (32)

    BPA is rapidly metabolised with glucuronidation conjugation. (33, 34)  Minor amounts of BPA are conjugated with sulphate and also, glutathione. (32)

    Transferases including sulfotransferases, glutathione-S-transferases (GSTs) are also involved in BPA conjugation. (35)

    A fraction of absorbed BPA may distribute to body storage site(s) such as adipose tissue, followed by a slow, low-level release of BPA into the bloodstream. (36)

    Phthalates

    Phthalates undergo a series of phase I hydrolysis and phase II conjugation reactions and are subsequently excreted in faeces and urine (37)

    Phthalates induce (cause overactivity) of cytochrome P450  (38) specifically CYP4 Enzymes. (7)

    Phthalates are a metabolite of glucuronidation, (39, 40) glycine & sulphation conjugation. (40, 41)

    Inhaled plastics

    Dioxins, furans & dioxin-like polychlorinated biphenyls (PCBs) are abbreviated names for a family of chemicals with similar toxicity & shared chemical characteristics. Dioxins & furans are inhaled & produced when plastic is burned. Dioxins & furans are also known as Tetrachlorodibenzo-p-dioxin (TCDD), the contaminant in Agent Orange (herbicide used in the Vietnam war).

    People vary in capacity to eliminate TCDD. The elimination rate is much faster at higher than lower levels. (42) TCDD induces a number of cytochrome P450 enzymes systems. (43)

    Accumulation of POPs, dioxins (43, 44) & furans induce cytochrome P450 enzyme systems. (45)
    Dioxins, furans & PCBs are metabolites of either glucuronidation or sulphate conjugation, mainly in the liver & then excreted in the bile or urine. (46)
    Dioxins undergo glutathione (47) sulfation, (48) glucuronidation (49) and Glycine conjugation phase II reactions. (50)

    Naturopathic Approaches to a Heavy Metal & Plastic Detoxification

    • Limit exposure
    • Place client on a limited therapeutic fast then detoxification diet
    • Support Phase 1 & II detoxification pathways using evidence based pharmacognosy (plant therapy), specifically inhibit Phase 1 P 450 and induce (speed up) Phase II reactions.
    • Apply chelation therapy using plant metallothioneins and phytochelatins found in herbs and foods.
    • Support eliminatory organ function.
    • Limit exposure
    • Avoid drinking out of plastic bottles.
    • Purchase the Carahealth Eco Water Filter

    Filters microplastics to 0.7 microns.
    Environmentally friendly solution.
    Address microplastic contamination
    Achieve chemical free drinking water.
    Place client on a limited therapeutic fast then a detoxification diet

    Fasting is Calorie Restriction (CR)

    The benefits of CR are scientific fact. A therapeutic fast simulates the Calorie Restrictive Diet that scientists have touted for the main reason behind Okinawan longevity.Like CR, fasting also activates telomerase the anti-ageing enzyme. Fasting, like CR, improves how cells respond to stress, how they break down (autophagy), induces apoptosis (programmed cell death ie in cancer cells),(51)and alters hormonal balance. Autophagy in particular, is quality control inside cells. It is essential to maintain cellular homeostasis and to improve how the cell responds to stress. Autophagic activity declines with age, therefore fasting is anti-ageing. CR is neuroprotective (protects brain cells). (52) In relation to heavy metal accumulation, CR/fasting enhances Phase II Detoxification specifically increasing glucuronidation and Glycine conjugation, thus will assist in the elimination of heavy metals. (3)

    Research shows dietary phytochemicals (chemicals in food) act as direct antioxidants to scavenge reactive oxygen species (free radicals). Dietary phytochemicals also regulate transcription factor Nrf2 [nuclear factor erythroid 2 (NF-E2). Nrf2 regulates the body's detoxification and antioxidant systems associated with phase II detoxification and antioxidant enzymes. (7) Metallothionein is a cysteine-rich protein that binds toxic metals such as mercury, cadmium, lead and arsenic.(4)Certain dietary patterns and nutrients increase metallothionein production. (7)

    Apply Pharmacognosy to support Phase 1 & II detoxification pathways & apply chelation therapy using plant Metallothionein & phytochelatins

    Why use Carahealth herbs?

    Carahealth tonics are 1:1 strength organic or wildcrafted extracts, meaning 1 part herb to one part alcohol. There is no point using non organic herbs to assist detoxification.All scientific studies in pharmacognosy use herbal medicine extracts, not weaker tinctures.

    The plan alternates 2 herbal detoxification tonics Carahealth Heavy Metal Detox and Carahealth Liver /Plastic Detox.

    Objectives in Heavy Metal Detoxification

    Apply Chelation therapy using plant metallothioneins and phytochelatins found in herbs
    Induce Nrf2 activity to increase phase II detoxification and support endogenous (made in our body) antioxidant enzymes.

    Carahealth Heavy Metal Detox (Carina’s 11 significant tonic decoction)

    The first 10 herbs are the traditional Chinese herbal formula Shi Quan Da Bu Tang (10 significant tonic decoction), the 11th herb is alfalfa.

    • Sheng Di huang Rehmannia glutinosa
    • Bai Shao Paeonia lactiflora
    • Chuan Xiong Liqusticum wallichii
    • Dang Gui Angelica sinensis
    • Gan Cao Glycyrrhiza uralensis
    • Gin Seng Panax ginseng
    • Huang Qi Astragalus membranaceus
    • Gui Zhi Cinnamomum cassia
    • Fu Ling Poria cocos
    • Bai Zhu Atractylodes macrocephala
    • Alfalfa Medicago sativa

    Pharmacognosy

    Shi Quan Da Bu Tang is traditionally used to tonify the Blood and Qi to treat anaemia, anorexia, extreme exhaustion, fatigue, kidney and spleen insufficiency and general weakness, particularly after illness and after chemotherapy. It has been found to potentiate (make it work better) chemotherapy and radiotherapy and inhibit malignant recurrences, prolong survival and prevent and ameliorate adverse toxicities in cancer treatment. (53) In Japanese herbal medicine (Kampo) the formula is known Juzen Taiho To and has been shown to increase expression of metallothioneins (MTs). (54) Shi Quan Da Bu Tang also increases transcription factor Nrf2 to support phase II detoxification thus regulate the body's detoxification and antioxidant system. (55) Alfalfa Medicago sativa contains heavy metal chelating plant metallothioneins. (5)

    Objectives in Plastic Detoxification

    Inhibit (slow down) Phase I P450 modification
    Induce (speed up) Phase II Conjugation

    Carahealth Liver Detox Tonic

    • Andrographis Andrographis paniculata
    • Milk thistle Silybum marianum
    • Bupleurum Bupleurum falcatum
    • Globe artichoke Cynara scolymus
    • Barberry Berberis vulgaris
    • Turmeric Curcuma longa

    Pharmacognosy

    Inhibit Phase I P450

    Andrographis Andrographis paniculata Chuan Xin Lian /King of the bitters

    Andrographis contains diterpenolactones which inhibits Phase I P450. (56)

    Milk thistle Silybum marianum

    Milk thistle significantly inhibits Phase I P 450. (57) The flavonolignans including silymarin(58)restore depleted glutathione (GSH) to assist glutathione conjugation. (59)

    Bupleurum Bupleurum falcatum Chai Hu

    Bupleurum contains saikosaponins which inhibit Phase I P450 enzymes (CYP1A2, CYP2C9 & CYP3A4) and flavonoids & steroids including, among others, rutin and quercetin which also inhibit Phase I P450 (CYP3A4). (56, 60)

    Inhibit Phase I P450 & induce Phase II

    Globe artichoke Cynara scolymus Yang Ji

    Globe artichoke contains the flavonoid luteolin which inhibits Phase I P 450 (CYP 3A4 & CYP3A5)(61) and also the hydroxycinnamic acid, cynarin which stimulates glucuronidation conjugation. Artichoke has potent antioxidant activity & reduces toxin-induced reduction of glutathione reserves. (62)

    Barberry Berberis vulgaris Fu Niu

    Barberry contains the benzylisoquinoline alkaloid berberine which inhibits Phase I P 450. (63)Berberine, specifically increases endogenous antioxidants, glutathione peroxidase (GPx) & superoxide dismutase (SOD), both copper-zinc SOD (CuZn-SOD) & manganese SOD (Mn-SOD) to assist glutathione conjugation. (64)

    Turmeric Curcuma longa Jiang Huang

    Turmeric contains the diarylheptanoid curcumin which inhibits Phase I P 450 while inducing Phase II. (65, 66) Curcumin restores depleted GSH to assist glutathione conjugation. (67)

    Curcumin also induces Nrf2 to increase antioxidant expression thereby protect against oxidative damage triggered by injury & inflammation. (68) Phase-II enzymes are regulated by Nrf2 which is involved in detoxification of AFB1.Aflatoxins B1 are genotoxic & carcinogenic compounds. Phase I P 450 enzymes are responsible for AFB1 bioactivation. Curcumin prevents AFB1-induced liver injury by modulating Phase I & Phase II enzymes. (69)

    For further details contact Carina Harkin  BHSc.Nat.BHSc.Hom.BHSc.Acu. This email address is being protected from spambots. You need JavaScript enabled to view it.

    1.Pumarega J, Gasull M, Lee D-H, López T, Porta M. Number of Persistent Organic Pollutants Detected at High Concentrations in Blood Samples of the United States Population. PLOS ONE. 2016;11(8):e0160432.

    2.Wong MH, Armour MA, Naidu R, Man M. Persistent toxic substances: sources, fates and effects. Reviews on environmental health. 2012;27(4):207-13.

    3.Wen H, Yang H-J, An YJ, Kim JM, Lee DH, Jin X, et al. Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies. Molecular & cellular proteomics : MCP. 2013;12(3):575-86.

    4.Metallothionein. Wikipedia2019.

    5.Robinson NJ, Tommey AM, Kuske C, Jackson PJ. Plant metallothioneins. The Biochemical journal. 1993;295 ( Pt 1)(Pt 1):1-10.

    6.Rea PA, Vatamaniuk OK, Rigden DJ. Weeds, Worms, and More. Papain's Long-Lost Cousin, Phytochelatin Synthase. 2004;136(1):2463-74.

    7.Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. Journal of nutrition and metabolism. 2015;2015:760689-.

    8.WHO. Health risks of heavy metals from long-range transboundary air pollution. Germany 2007.

    9.Jarup L. Hazards of heavy metal contamination. Br Med Bull. 2003;68:167-82.

    10.Kim H, Jin Kim Y, Rok Seo Y. An Overview of Carcinogenic Heavy Metal: Molecular Toxicity Mechanism and Prevention2015. 232-40 p.

    11.Jambeck JR, Geyer R, Wilcox C, Siegler TR, Perryman M, Andrady A, et al. Marine pollution. Plastic waste inputs from land into the ocean. Science (New York, NY). 2015;347(6223):768-71.

    12.Mary Kosuth SMaEW. Anthropogenic contamination of tap water, beer, and sea salt. Plos One. 2018 April 11.

    13.Mary Kosuth EVW, Sherri A. Mason, Christopher Tyree, Dan Morrison. Synthetic polymer contamination in Global drinking Water [Interent]. ORB 2017 May 16 [Available from: https://orbmedia.org/stories/invisibles_final_report/multimedia.

    14.Anne Marie Mahon RO, Róisín Nash and Ian O’Connor. Research 210:Scope, Fate, Risks and Impacts of Microplastic Pollution in Irish Freshwater Systems. EPA GMIT; 2014.

    15.Mason SA, Welch VG, Neratko J. Synthetic Polymer Contamination in Bottled Water. Frontiers in chemistry. 2018;6:407-.

    16.Westerhoff P, Prapaipong P, Shock E, Hillaireau A. Antimony leaching from polyethylene terephthalate (PET) plastic used for bottled drinking water. Water research. 2008;42(3):551-6.

    17.Editor KOSES. Nine different plastics found in human stools, research shows. The Irish Times. 2018 Oct 23.

    18.Thompson A. Microplastics Have Been Found in People's Poop—What Does It Mean? Scientific American. 2018 Oct 24.

    19.Wright SL, Kelly FJ. Threat to human health from environmental plastics. 2017;358.

    20.Åke Bergman JJH, Susan Jobling, Karen A. Kidd and R. Thomas Zoeller. State of the Science of Endocrine Disrupting Chemicals Geneva: WHO UNEP Inter-organisation programme fro the sound managemnt of chemicals: A cooperative agreement among FAO, ILO, UNDP, UNEP, UNIDO, UNITAR, WHO, World Bank and OECD; 2012.

    21.Hood E. Are EDCs blurring issues of gender? Environmental health perspectives. 2005;113(10):A670-A7.

    22.Huo X, Chen D, He Y, Zhu W, Zhou W, Zhang J. Bisphenol-A and Female Infertility: A Possible Role of Gene-Environment Interactions. International journal of environmental research and public health. 2015;12(9):11101-16.

    23.Zeliger HI. Exposure to lipophilic chemicals as a cause of neurological impairments, neurodevelopmental disorders and neurodegenerative diseases. Interdisciplinary toxicology. 2013;6(3):103-10.

    24.Le Magueresse-Battistoni B, Labaronne E, Vidal H, Naville D. Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders. World journal of biological chemistry. 2017;8(2):108-19.

    25.Robinson L, Miller R. The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings. Current environmental health reports. 2015;2(4):379-87.

    26.COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CPATEC. NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES) - INTRODUCTION 2010

    27.Takayuki Nakahama YIaMF. Comparative Study on in vitro Inhibitory Effects of Heavy Metals on Rabbit Drug-Metabolizing Enzymes. Journal of Health Science. 2001;47(1):14–20.

    28.Bruschweiler BJ, Wurgler FE, Fent K. Inhibitory effects of heavy metals on cytochrome P4501A induction in permanent fish hepatoma cells. Archives of environmental contamination and toxicology. 1996;31(4):475-82.

    29.Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. Experientia supplementum (2012). 2012;101:133-64.

    30.Takeshita A, Koibuchi N, Oka J, Taguchi M, Shishiba Y, Ozawa Y. Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. European journal of endocrinology. 2001;145(4):513-7.

    31.Niwa T, Fujimoto M, Kishimoto K, Yabusaki Y, Ishibashi F, Katagiri M. Metabolism and interaction of bisphenol A in human hepatic cytochrome P450 and steroidogenic CYP17. Biological & pharmaceutical bulletin. 2001;24(9):1064-7.

    32.Jaeg JP, Perdu E, Dolo L, Debrauwer L, Cravedi JP, Zalko D. Characterization of new bisphenol a metabolites produced by CD1 mice liver microsomes and S9 fractions. Journal of agricultural and food chemistry. 2004;52(15):4935-42.

    33.Ginsberg G, Rice DC. Does rapid metabolism ensure negligible risk from bisphenol A? Environmental health perspectives. 2009;117(11):1639-43.

    34.Fay MJ, Nguyen MT, Snouwaert JN, Dye R, Grant DJ, Bodnar WM, et al. Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family. Drug Metab Dispos. 2015;43(12):1838-46.

    35.Shmarakov IO, Borschovetska VL, Blaner WS. Hepatic Detoxification of Bisphenol A is Retinoid-Dependent. Toxicological sciences : an official journal of the Society of Toxicology. 2017;157(1):141-55.

    36.Koch HM, Calafat AM. Human body burdens of chemicals used in plastic manufacture. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2009;364(1526):2063-78.

    37.Frederiksen H, Skakkebaek NE, Andersson A-M. Metabolism of phthalates in humans. 2007;51(7):899-911.

    38.Takeshita A, Igarashi-Migitaka J, Nishiyama K, Takahashi H, Takeuchi Y, Koibuchi N. Acetyl Tributyl Citrate, the Most Widely Used Phthalate Substitute Plasticizer, Induces Cytochrome P450 3A through Steroid and Xenobiotic Receptor. Toxicological Sciences. 2011;123(2):460-70.

    39.Stein TP, Schluter MD, Steer RA, Ming X. Autism and phthalate metabolite glucuronidation. Journal of autism and developmental disorders. 2013;43(11):2677-85.

    40.Walter J. Crinnion JEP. Clinical Environmental Medicine. Identification and Natural Treatment of Diseases Caused by Common Pollutants. Elsevier; 2018 April 26. p. 97.

    41.Phthalate NRCUCotHRo. Phthalates and Cumulative Risk Assessment: The Tasks Ahead.: National Academies Press; 2008.

    42.Marinkovic N, Pasalic D, Ferencak G, Grskovic B, Stavljenic Rukavina A. Dioxins and human toxicity. Arhiv za higijenu rada i toksikologiju. 2010;61(4):445-53.

    43.Schrenk D. Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of endo- and xenobiotics. Biochemical pharmacology. 1998;55(8):1155-62.

    44.Kubota A, Watanabe MX, Kim EY, Yoneda K, Tanabe S, Iwata H. Accumulation of dioxins and induction of cytochrome P450 1A4/1A5 enzyme activities in common cormorants from Lake Biwa, Japan: temporal trends and validation of national regulation on dioxins emission. Environ Pollut. 2012;168:131-7.

    45.Harrad S. Persistent Organic Pollutants: Environmental Behaviour and Pathways of Human Exposure Harrad S, editor. West Sussex, United Kingdom: Chichester; 2001 Edition, .

    46.Daidoji T, Gozu K, Iwano H, Inoue H, Yokota H. UDP-GLUCURONOSYLTRANSFERASE ISOFORMS CATALYZING GLUCURONIDATION OF HYDROXY-POLYCHLORINATED BIPHENYLS IN RAT. 2005;33(10):1466-76.

    47.Odell GB, Mogilevsky WS, Smith PB, Fenselau C. Identification of glutathione conjugates of the dimethyl ester of bilirubin in the bile of Gunn rats. Molecular pharmacology. 1991;40(4):597-605.

    48.Dhakal K, He X, Lehmler H-J, Teesch LM, Duffel MW, Robertson LW. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chemical research in toxicology. 2012;25(12):2796-804.

    49.Bank PA, Salyers KL, Zile MH. Effect of tetrachlorodibenzo-p-dioxin (TCDD) on the glucuronidation of retinoic acid in the rat. Biochimica et biophysica acta. 1989;993(1):1-6.

    50.Tarloff J.B. GRS, Hook J.B. Xenobiotic Metabolism in the Mammalian Kidney. Bach P.H. LEA, editor: Springer, Dordrecht; 1987.

    51.Makino N, Oyama J-i, Maeda T, Koyanagi M, Higuchi Y, Tsuchida K. Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts. Molecular and cellular biochemistry. 2015;403(1-2):1-11.

    52.Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain research reviews. 2009;59(2):293-315.

    53.Chang I-M. Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Application. Evidence-based Complementary and Alternative Medicine. 2006;3(3):393-4.

    54.Anjiki N, Hoshino R, Ohnishi Y, Hioki K, Irie Y, Ishige A, et al. A kampo formula Juzen-taiho-to induces expression of metallothioneins in mice. 2005;19(10):915-7.

    55.Wu Q, Zhang D, Tao N, Zhu QN, Jin T, Shi JS, et al. Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs. Am J Chin Med. 2014;42(1):207-21.

    56.Mohamed L Ashour FSY, Haidy A Gad, Michael Wink2. Inhibition of Cytochrome P450 (CYP3A4) Activity by Extracts from 57 Plants Used in Traditional Chinese Medicine (TCM). Pharmacogn Mag. 2016.

    57.Kawaguchi-Suzuki M, Frye RF, Zhu H-J, Brinda BJ, Chavin KD, Bernstein HJ, et al. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug metabolism and disposition: the biological fate of chemicals. 2014;42(10):1611-6.

    58.Polyak SJ, Morishima C, Lohmann V, Pal S, Lee DYW, Liu Y, et al. Identification of hepatoprotective flavonolignans from silymarin. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(13):5995-9.

    59.Kim YC, Na JD, Kwon DY, Park JH. Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in mice. Journal of Functional Foods. 2018;49:235-40.

    60.Yu T, Chen X, Wang Y, Zhao R, Mao S. Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro. Xenobiotica; the fate of foreign compounds in biological systems. 2014;44(10):861-7.

    61.Quintieri L, Palatini P, Nassi A, Ruzza P, Floreani M. Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. Biochemical pharmacology. 2008;75(6):1426-37.

    62.Gebhardt R. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicology and applied pharmacology. 1997;144(2):279-86.

    63.Guo Y, Chen Y, Tan ZR, Klaassen CD, Zhou HH. Repeated administration of berberine inhibits cytochromes P450 in humans. European journal of clinical pharmacology. 2012;68(2):213-7.

    64.Lao-ong T, Chatuphonprasert W, Nemoto N, Jarukamjorn K. Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine. Pharmaceutical biology. 2012;50(8):1007-12.

    65.Muhammad I, Wang H, Sun X, Wang X, Han M, Lu Z, et al. Dual Role of Dietary Curcumin Through Attenuating AFB(1)-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB(1) Bioactivation and Detoxification. Frontiers in pharmacology. 2018;9:554-.

    66.Krishnaswamy K, Goud VK, Sesikeran B, Mukundan MA, Krishna TP. Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin. Nutrition and cancer. 1998;30(2):163-6.

    67.Jagatha B, Mythri RB, Vali S, Bharath MM. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free radical biology & medicine. 2008;44(5):907-17.

    68.NFE2L2protein that regulates the expression of antioxidant proteins. Wikipedia2018.

    69.Muhammad I, Wang H, Sun X, Wang X, Han M, Lu Z, et al. Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification. Front Pharmacol. 2018;9:554.

  • Heavy Metal Plastics Detox

  • Practitioner Strength Organic or Wildcrafted Herbal Extracts

  • Ketogenic Diets stabilises blood sugar, reduces cravings, improves insulin sensitivity, treats metabolic syndrome & central obesity, assists fat metabolism, tonifies the thyroid gland to boost the Basal Metabolic Rate.

    Your Practitioner

    To achieve a state of ketosis By prescribing a Low GI carbohydrate restricted diet, forcing fat to be broken down to form ketones which are used instead of glucose as fuel for healthy body cells. Suitable for vegetarians/vegans.

    Benefits of a Keto Diet

    • Lowers cholesterol and triglycerides
    • Induces rapid weight loss, in particular abdominal fat.
    • Lowers blood sugar
    • Improves energy
    • Suppresses hunger

    What to expect?

    Your ketogenic diet and weight loss consultations

    The first consultation will ascertain what you eat and make recommendations for a ketosis diet that suits you.

    The second consultation will ensure firstly, that you have achieved a state of ketosis and secondly to address any issues you have surrounding the dietary recommendations.

    The third consultation will assist you in moving from Phase 1 (short-term) into Phase 2 (long-term) of the diet. This occurs when you are near your goal weight. Phase 2 is the Keto Diet for Health and longevity, mimics fasting and is life extending.
    Keto Diet for Weight Loss

    This diet is a carbohydrate restrictive, high good fat, high healthy protein (including veg/vegan based protein) diet. Ketosis is a perfectly normal metabolic process. When we are unable to use carbohydrates as fuel for cells to burn for energy, fats are used instead. Ketones are produced as part of this process. In fact, ketones are the preferred source of fuel for our bodies. This diet is suitable for vegetarians/vegans. 

    Benefits of a Ketogenic Diet

    Lowers cholesterol: Lowers LDL & triglyceride levels and raises HDL (good cholesterol). (1)

    Induce Rapid Weight Loss: Reduces body weight and body mass index. (1)

    Lowers Blood Sugar: Studies show a ketosis diet can eliminate type 2 diabetes. (2, 3)

    Enhances physical and cognitive performance: Ketone bodies are the most energy-efficient fuel and yield more ATP. (4)

    Suppresses Appetite: High fats diets increase satiety. (5)

    Starve Cancer Cells: Cancer cells need glucose for fuel. Only healthy cells can live on ketones. Studies indicate a ketosis diet is an adjunct therapeutic aid in cancer. (6, 7)

    Treats neurodegenerative disease: Ketosis is neuroprotective and neuroregenerative (8) & therapeutic treatment in traumatic head injury, neurological disease (9) including Parkinson’s, Alzheimer's (10) & epilepsy, (11)

    Extends Life: The benefits of Calorie restriction/Keto diet are scientific fact. A Ketosis diet simulates the Calorie Restrictive Diet (12) that scientists have touted for the main reason behind Okinawan longevity. Like CR, Ketosis also activates telomerase the anti-ageing enzyme. Calorie restriction increases telomerase activity and enhances autophagy (breakdown of dead cells). (13) CR improves how cells respond to stress, how they break down (autophagy), induces apoptosis (programmed cell death ie in cancer cells), and alters hormonal balance. Autophagy in particular, is quality control inside cells. It is essential for the maintenance of cellular homeostasis and for the orchestration of an efficient cellular response to stress. Autophagic activity declines with age, and this contributes to the ageing process. (14)

    Carina Harkin BHSc.Acu.BHSc.Nat.BHSc.Hom. Cert IV TAE. This email address is being protected from spambots. You need JavaScript enabled to view it.

    1. Dashti HM, Mathew TC, Hussein T, Asfar SK, Behbahani A, Khoursheed MA, et al. Long-term effects of a ketogenic diet in obese patients. Experimental and clinical cardiology. 2004;9(3):200-5.

    2. Westman EC, Tondt J, Maguire E, Yancy WS, Jr. Implementing a low-carbohydrate, ketogenic diet to manage type 2 diabetes mellitus. Expert review of endocrinology & metabolism. 2018;13(5):263-72.

    3. Yancy WS, Jr., Foy M, Chalecki AM, Vernon MC, Westman EC. A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutrition & metabolism. 2005;2:34-.

    4. Murray AJ, Knight NS, Cole MA, Cochlin LE, Carter E, Tchabanenko K, et al. Novel ketone diet enhances physical and cognitive performance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016;30(12):4021-32.

    5. Gibson AA, Seimon RV, Lee CMY, Ayre J, Franklin J, Markovic TP, et al. Do ketogenic diets really suppress appetite? A systematic review and meta-analysis. 2015;16(1):64-76.

    6. Klement RJ. Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation. Medical oncology (Northwood, London, England). 2017;34(8):132.

    7. Morscher RJ, Aminzadeh-Gohari S, Feichtinger RG, Mayr JA, Lang R, Neureiter D, et al. Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model. PLOS ONE. 2015;10(6):e0129802.

    8. Shaafi S, Mahmoudi J, Pashapour A, Farhoudi M, Sadigh-Eteghad S, Akbari H. Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages. Advanced pharmaceutical bulletin. 2014;4(Suppl 2):479-81.

    9. Gano LB, Patel M, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. Journal of lipid research. 2014;55(11):2211-28.

    10. Włodarek D. Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease). . Nutrients. 2019;11(169).

    11. Agarwal N, Arkilo D, Farooq O, Gillogly C, Kavak KS, Weinstock A. Ketogenic diet: Predictors of seizure control. SAGE open medicine. 2017;5:2050312117712887-.

    12. Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain research reviews. 2009;59(2):293-315.

    13. Wang B-H, Hou Q, Lu Y-Q, Jia M-M, Qiu T, Wang X-H, et al. Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures. Brain Research. 2018;1678:106-15.

    14. Veech RL, Bradshaw PC, Clarke K, Curtis W, Pawlosky R, King MT. Ketone bodies mimic the life span extending properties of caloric restriction. 2017;69(5):305-14.

  • Liver Detox Tincture

  • Image

    The National Acupuncture Detoxification Association (NADA) auricular ear acupuncture protocol, is used globally to deal with and recover from substance abuse, addiction & assist detoxification.

  • food allergies

    Food allergy is an abnormal response to a food triggered by your immune system. Symptoms include itchiness, swelling, vomiting, diarrhea, trouble breathing, or low blood pressure.

  • Childhood Obesity

    Central obesity is as much linked to cardiovascular disease as cigarette smoking? Obesity is associated with complications in pregnancy, heart disease, late onset diabetes and certain cancers, in particular those related to oestrogen and the gastrointestinal tract.

  • A Naturopathic Consultation is holistic and assesses the physical, psychological, emotional and spiritual aspects of a person. For example from a Western Medical Perspective you may be medically diagnosed with hypothyroidism however, from a Naturopathic Medical Perspective your diagnosis might be;

    Practitioner

    • Decreased Basal Metabolic Rate (BMR) due to "Functional Hypothyroid"
    • Poor breakdown of fats and increased visceral adiposity due to a "Sluggish Liver".
    • Excess cravings for carbohydrates due to “Insulin Resistance” and "Functional Hypoglycemia"
    • Long term stress leading to "Adrenal Exhaustion", cortisol spikes and resultant weight gain
    • Long term stress leading to “Nervous System Exhaustion” and emotional eating
    • Nutritional deficiencies of Iodine, EFAs, selenium
    • Excess Bioaccumulation of endocrine disrupting chemicals (EDCs) such as fluoride, aluminium and  BPA leading to a disruption of thyroid hormone production. 

    Thus

    Naturopathic Treatment Principles 

    • Tonify the thyroid to boost BMR
    • Improve insulin sensitivity
    • Balance blood sugar
    • Tonify the adrenal gland
    • Nourish the nervous system
    • Replace nutritional deficiencies
    • Treatment in the terms of dietary, lifestyle, supplement and herbal medicine recommendations are then derived from these treatment principles.

    Addtional Protocols

    Traditional Chinese Medicine

    As an Acupuncturist, I will also diagnose your Pattern of Disharmony according to Traditional Chinese Medicine. In obesity, it may be for example Cold Damp accumulation due to Spleen Qi and Yang Deficiency. I will prescribe Acupuncture, Chinese Herbal Medicine and Chinese Dietary Therapy to treat your Pattern of Disharmony. Rather than prescribing Chinese Herbal Patent Formulas, I specialise in preparing Traditional Chinese Herbal Formulations in organic 1:1 high practitioner strength extract form 

    Once I have confirmed a Naturopathic Diagnosis, I will then explain the Naturopathic Causes of your condition from a Naturopathic Perspective so that you will be motivated to remove these causes to the best of your ability and have a better chance for cure, depending also, on the strength of your Vital Force. As the "Stress-Less Naturopath" I tailor a Health Management Solution to suit your lifestyle.

    I am trained in pharmacology, herbal and supplement contraindications and drug/nutrient, drug/herb interactions. I can prescribe safely if you are pregnant and breastfeeding or on medication. As a Herbalist and Nutritionist I specialise in matching the pharmacological actions of drugs with natural alternatives using compounds found in food and herbs. I will always give dietary advice and assess your diet for nutritional deficiencies.

    Classical Homeopathy

    As a classical homeopath I may also prescribe what are described as your constitutional remedy, an acute lesional remedy or drainage remedy.

    What to expect during a Naturopathic consultation?

    At either a consult in person or an online consultation I will

    Discuss your presenting symptoms

    • Discuss any medications that you take to ensure that there are no drug/nutrient or drug/herb contraindications with proposed or current treatment
    • Discuss your past health history
    • Discuss your family history
    • Ask you questions about relevant body systems to gain a better understanding of your condition
    • Perform nail analysis and tongue and pulse diagnosis to asses for mineral deficiencies (For online consult you will need to email photo of tongue)
    • Perform Iridology (for online consult you will need to attach photo of left and right iris)
    • Take your blood pressure
    • May recommend blood or other tests
    • Explain the Naturopathic Causes of your health issues from a Naturopathic Medical Perspective
    • Provide a diagnosis from a Chinese Medical Perspective
    • Prescribe treatment in the terms of diet, (including Chinese dietary therapy), lifestyle, herbal medicine, homeopathy and supplements in the form of an email prescription.
    • Provide ongoing support through www.carahealth.com Online Naturopathic Health Resource and Consultant Services.
    • Face-to-face consultation includes acupuncture according to your Pattern of Disharmony.

    For further details contact Carina This email address is being protected from spambots. You need JavaScript enabled to view it.

     

  • For a Natural Performance Boost,  three seperate consultations are reccomended, teaching about performance enhancing supplements, Carbohydrate loading, training tactics & match day diet, Fuelling tactics, Weight gain & Hyper-hydration.

    The plan adapts WHO guidelines and sports nutrition protocols recommended by the Australian Institute of Sport and the adoption of legal ergogenic performance enhancing herbs & supplements.

    Practitioner

    Goals;

    To achieve energy balance & healthy BMI
    Reduce saturated fats & trans-fatty acids
    Increase consumption of omega 3 healthy fats
    Increase consumption of fruits, vegetables, legumes, whole grains & nuts
    Limit the intake of simple sugars
    Limit salt / sodium consumption from all sources
    Ensure sufficient essential amino acids to assist immune system & repair
    Include essential vitamins & minerals
    Avoiding directly poisonous (e.g. heavy metals) & carcinogenic (e.g. benzene) substances.
    Learn about performance enhancing supplement recommendations according to the Australian Institute of Sport including;

    • Carbohydrate loading
    • The training & match day diet
    • Training tactics
    • Fuelling tactics
    • Meal timing
    • Weight gain
    • Hyper-hydration
    • Evidence based herbal ergogenic/ performance-enhancing aids are prescribed to enhance physical strength and performance capacity.

    What to expect

    1st Consultation

    Involves discussing presenting symptoms including and medications/supplements that you take to ensure that there are no drug/nutrient or drug/herb contraindications with proposed or current treatment. Next we will discuss your past medical and family history. Then I will ask questions about relevant body systems to gain a better understanding of your general health. I will assess your Basal Metabolic Index (BMI) to ascertain where you stand in relation to being a healthy weight. I will assess your current diet to ensure it contains sufficient essential amino acids, vitamins and minerals to assist body function such as immune system and repair and to look for specific nutritional deficiencies and to assess your diet and lifestyle to ensure you are avoiding poisonous and carcinogenic substances.

    Your diet plan will;

    • Make tailored dietary recommendations to address any specific deficiencies or issues
    • Provide advice on healthy fats
    • Provide advice on low GI fruits and vegetables, legumes, whole grains and nuts to sustain energy levels
    • Provide advice on healthy low GI sugar alternatives
    • Provide advice on healthy salt alternatives
    • Provide advice on healthy snacks

    Your prescription will provide a performance enhancing diet plan and lifestyle, herbal medicine and supplements advice in the form of an email prescription.

    2nd Consultation

    Involves discussing a tailored training diet plan to provide sufficient levels of all nutrients and sustained, slow release low GI carbohydrates to help provide energy for long and intense training sessions. The plan is a general guide, and portion sizes will need to be adapted to suit your daily routine.

    We will also discuss;

    Carbohydrate loading and performance enhancement the original and modern carb loading and how taper your exercise before the match/sporting event

    • The Training Diet
    • Match Day Diet
    • Training tactics
    • Fuelling Tactics
    • Meal Timing
    • Weight gain
    • Fluids Hyper-hydration

    3rd Consultation

    Aims to ensure you are on track and address any pitfalls you may be experiencing and how to overcome them. You will be provided with more recipes that tick all boxes for essential healthy proteins, carbohydrates and fat and essential vitamins and minerals to promote recovery from injury and enhance performance.

    Herbal Medicine as a performance booster to enhance athletic performance

    Performance-enhancing substances enhance physical strength to improve performance. A performance boosteris also called an ergogenic aid. (1) Herbal medicine adaptogens acts as ergogenic aids to enhance performance. Frome a herbal medicine perspective adaptogens, testosteromimetic and caffeine rich herbs are ergogenic aids.

    Carahealth uses high strength practitioner only, organic or wild crafted extracts. Tonics are 1:1 strength, 3 x stronger than available in health food stores or herbs used by other practitioners.

    Herbal Medicine Protocol 

    Adaptogen Herbs

    Adaptogens increase resilience to stress whether it is physical, chemical, biological or emotional in origin. Adaptogens restore and normalise physiological functions in the event of stress allowing us to handle the stressful situations in a more resourceful manner. Adaptogens specifically help our bodies adapt to changes in our circadian rhythm caused by hectic lifestyles (2) or deficiency in sunlight. Current uses of adaptogens relate mainly to treating stress-induced fatigue, improving cognitive function and treating emotional and behavioural disorders. Adaptogens also protect against chronic inflammation, atherosclerosis, neurodegenerative cognitive impairment, metabolic disorders, and other age-related disease. (3)

    Ginseng Asian ginseng Chinese,/Korean ginseng Panax ginseng 

    Panax ginseng, also known as Chinese or Korean ginseng, is the one which is most widely used ergogenic aids. (4) Ginseng is a tonic herb that improves vitality, health and longevity. Ginseng is an adaptogen and enhance endurance and strength. Ginseng root increases muscular strength and aerobic work capacity. It has been reported that the use of ginseng does not lead to any positive test results for banned substances after urine testing of elite athletes, although ginsenosides and their metabolites are detectable in the sera and urine of athletes following the ingestion of ginseng.

    Ginseng roots;

    • Stimulate and protects the central nervous system. (5)
    • Enhances cognitive function and improves mood. (6)
    • Increased production of corticotropin and cortisol and has anabolic actions. (7)
    • Has potent adaptogenic activity that is mediated by regulation of pituitary adrenocorticotropic hormone secretion to combat stress. (8)
    • Possess antioxidant properties and inhibits lipid peroxidation. (9)
    • Has stimulant effect and thus improves alertness and decreases fatigue and stress
    • Increases exercise time to exhaustion. (10)
    • Protects against cardiovascular disease. (11)
    • Supports male reproductive function. (12)

    Siberian ginseng Eletherococcus senticosus 

    Studied extensively by Russian researchers, Siberian ginseng is distantly related to the Panax species. Siberian ginseng contains unique steroidal saponins termed eleutherosides that appear to be structurally similar to, but are distinct from, Panax ginsenosides. Siberian ginseng improves muscular strength, resistance to fatigue and recovery from exercise.

    Siberian ginseng;

    • Supports healthy ageing and improves quality of life. (13)
    • Protects against cardiovascular disease. (14)
    • Is immune stimulatory, has various anti-cancer properties and possesses anti-tumour effects. (15)
    • Protect against cancer formation by inducing apoptosis (programmed cell death) (16)
    • Reduces fatigue. (17)

    Withania Ashwagandha/ Indian Ginseng Withania somnifera 

    Withania is an adaptogen and enhances endurance and strength. A study aimed to determine the effect of Ashwagandha on the cardiorespiratory endurance capacity, that is, aerobic capacity in elite Indian cyclists found there was significant improvement in the experimental group in all parameters in terms of maximal aerobic capacity (VO2 max), metabolic equivalent, respiratory exchange ratio (RER), and total time for the athlete to reach his exhaustion stage. (18)

    Withania ginseng;

    • Reduces stress and anxiety. (19)
    • Displays anti cancer effects. (20, 21)
    • Is chemoprotective (protects against chemical damage). (22)
    • Is neuroprotective to protect against neurodegenerative disease such as stroke and Alzheimer’s. (23)

    Rhodiola Rhodiola rosea 

    Rhodiola is an adaptogen, enhances endurance and strength. A study to determine the effects o Rhodiola rosea on endurance exercise performance, perceived exertion, mood, and cognitive function found acute Rhodiola rosea ingestion decreases heart rate response to submaximal exercise and appears to improve endurance exercise performance by decreasing the perception of effort. (24)

    Rhodioloa;

    • Improves endurance exercise performance. (25)
    • Alleviates stress, anxiety and depression by increasing feel-good hormones. (26-29)
    • Enhances cognitive function (30) and metal and physical performance. (31)
    • Reduces physical and mental fatigue. (32)
    • Is anti-inflammatory and neuroprotective. (33)

    Testoteromimetic herbs

    Testosteromimetic herbs increase testosterone thus are anabolic, can improve recovery time from resistance exercise and enhance strength. The following herbs increase testosterone levels. Women also make and utilise testosterone so these herbs are safe for use my women as an ergogenic aid during training and performance.

    Sarsaparilla Smilax ornata 

    In Traditional Chinese Medicine is traditionally used to treat sexual hypofunction. Sarsaparilla has a beneficial effect on exercise performance. (34)

    Sarsaparilla

    • Has a testostermomimetic effects thereby increases testosterone so is anabolic.(35)
    • Is a herbal aphrodisiac. (36)

    Tribulus Tribulus terrestra 

    Sarsaparilla has testostermomimetic so is anabolic. It contains a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. T. terrestris did not alter the urinary T/E ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agency's urinary T/E ratio limit.

    Tribulus

    • Increases strength and fat free mass. (37)
    • Is a male reproductive tonic and improves fertility. (38-40)
    • Is an aphrodisiac and performance enhancer. (41)

    Caffeine rich herbs

    Caffeine supplementation improves performance at varying intensities and modalities of exercise. Caffeine is a well-documented stimulant of the central nervous system as well as the cardiovascular and respiratory systems. Caffeine ingestion increases blood catecholamine concentration. Caffeine's ergogenic effect on sports performance is also attributed to its effect on substrate availability, namely, free fatty acids. Increases in free fatty acid concentration in turn lead to a glycogen-sparing effect because the body's energy system will start using free fatty acid as a primary source of fuel. A significant increase (44%) in endurance running performance is achieved after athletes ingested 9 mg/kg body mass of caffeine 1 hour prior to exercise.

    Kola nut Cola nitida 

    Kola nut is a naturally rich source of caffeine. But unlike caffeine, kola nut is rich in vitamins and minerals so has a lot of health benefits. Kola nut is high in antioxidant polyphenols, it is anti-bacterial, rich in theobromine content, which is a vasodilator hence a circulatory stimulant.

    Kola nut

    • Improves locomotor function. (42)
    • Is antioxidant rich and inhibits lipid peroxidation. (43)
    • Is chemoprotective and has been shown to inhibit androgen dependent cancers in males. (44)

    Carahealth PerformanceTonic

    Formulated to help improve exercise performance capacity or enhance physical strength. The tincture contains a blend of adaptogenic herbs and herbs that increase testosterone hence is anabolic. The tincture also contains a caffeine rich herb.

    Ingredients: Chinese ginseng, Siberian ginseng, Indian Ginseng , Rhodiola, Sarsaparilla, Tribulus & Kola nut.

    Actions ;

    Lowers cortisol levels during times of stress
    Boosts immunity
    Increases energy levels
    Improves resistance to stress
    Improves concentration
    Enhances recovery from resistance exercise
    Enhances strength
    Increase muscle mass
    Stimulates the central nervous system
    Stimulates the cardiovascular and respiratory systems

    Ketosis Diet as an ergogenic training aid

    A long-term ketosis, high fat, low carbohydrate diet may be favourable for aerobic endurance athletes, during the preparatory season, when a high volume and low to moderate intensity of training loads predominate in the training process. Fat loading slows down the rate of carbohydrate utilization and enhance endurance performance in long distance events lasting from 2 to 5 h. This is especially true during long-term ketogenic diets, where the body adapts to increased fat oxidation through enzymatic and endocrine changes

    A ketogenic diet has been used by professional cyclists. A ketogenic diet is a diet high in lipids and low in carbohydrates for ~4 days to induce nutritional ketosis. However a ketogenic diet may impair exercise performance via reducing the capacity to utilise carbohydrate, which forms a key fuel source for skeletal muscle during intense endurance-type exercise so is only recommender during training periods only. (45)

    For further details contact Carina This email address is being protected from spambots. You need JavaScript enabled to view it. 

    1. Thein LA, Thein JM, Landry GL. Ergogenic aids. Physical therapy. 1995;75(5):426-39.

    2. Panossian A, Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals (Basel, Switzerland). 2010;3(1):188-224.

    3. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Annals of the New York Academy of Sciences. 2017;1401(1):49-64.

    4. Lee NH, Jung HC, Lee S. Red Ginseng as an Ergogenic Aid: A Systematic Review of Clinical Trials. Journal of exercise nutrition & biochemistry. 2016;20(4):13-9.

    5. Rokot NT, Kairupan TS, Cheng K-C, Runtuwene J, Kapantow NH, Amitani M, et al. A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders. Evidence-based complementary and alternative medicine : eCAM. 2016;2016:2614742-.

    6. Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacology Biochemistry and Behavior. 2003;75(3):687-700.

    7. Choi JY, Woo TS, Yoon SY, Ike Campomayor Dela P, Choi YJ, Ahn HS, et al. Red ginseng supplementation more effectively alleviates psychological than physical fatigue. Journal of ginseng research. 2011;35(3):331-8.

    8. Liao L-Y, He Y-F, Li L, Meng H, Dong Y-M, Yi F, et al. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chinese medicine. 2018;13:57-.

    9. Chung SI, Kang MY, Lee SC. In Vitro and In Vivo Antioxidant Activity of Aged Ginseng (Panax ginseng). Preventive nutrition and food science. 2016;21(1):24-30.

    10. Sellami M, Slimeni O, Pokrywka A, Kuvačić G, D Hayes L, Milic M, et al. Herbal medicine for sports: a review. Journal of the International Society of Sports Nutrition. 2018;15:14-.

    11. Kim J-H. Cardiovascular Diseases and Panax ginseng: A Review on Molecular Mechanisms and Medical Applications. Journal of ginseng research. 2012;36(1):16-26.

    12. Leung KW, Wong AS. Ginseng and male reproductive function. Spermatogenesis. 2013;3(3):e26391-e.

    13. Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi A. Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Archives of gerontology and geriatrics Supplement. 2004(9):69-73.

    14. Kwan C-Y, Zhang W-B, Sim S-M, Deyama T, Nishibe S. Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Naunyn-Schmiedeberg's Archives of Pharmacology. 2004;369(5):473-80.

    15. Cichello SA, Yao Q, Dowell A, Leury B, He XQ. Proliferative and Inhibitory Activity of Siberian ginseng (Eleutherococcus senticosus) Extract on Cancer Cell Lines; A-549, XWLC-05, HCT-116, CNE and Beas-2b. Asian Pac J Cancer Prev. 2015;16(11):4781-6.

    16. Kim CG, Castro-Aceituno V, Abbai R, Lee HA, Simu SY, Han Y, et al. Caspase-3/MAPK pathways as main regulators of the apoptotic effect of the phyto-mediated synthesized silver nanoparticle from dried stem of Eleutherococcus senticosus in human cancer cells. Biomedicine & Pharmacotherapy. 2018;99:128-33.

    17. Hartz AJ, Bentler S, Noyes R, Hoehns J, Logemann C, Sinift S, et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychological medicine. 2004;34(1):51-61.

    18. Shenoy S, Chaskar U, Sandhu JS, Paadhi MM. Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists. Journal of Ayurveda and integrative medicine. 2012;3(4):209-14.

    19. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine. 2012;34(3):255-62.

    20. KHAZAL KF, SAMUEL T, HILL DL, GRUBBS CJ. Effect of an Extract of Withania somnifera Root on Estrogen Receptor-positive Mammary Carcinomas. 2013;33(4):1519-23.

    21. Prakash J, Gupta SK, Dinda AK. Withania somnifera root extract prevents DMBA-induced squamous cell carcinoma of skin in Swiss albino mice. Nutrition and cancer. 2002;42(1):91-7.

    22. Prakash J, Gupta SK, Kochupillai V, Singh N, Gupta YK, Joshi S. Chemopreventive activity of Withania somnifera in experimentally induced fibrosarcoma tumours in Swiss albino mice. Phytotherapy research : PTR. 2001;15(3):240-4.

    23. Raghavan A, Shah ZA. Withania somnifera: a pre-clinical study on neuroregenerative therapy for stroke. Neural regeneration research. 2015;10(2):183-5.

    24. Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. Journal of strength and conditioning research. 2013;27(3):839-47.

    25. De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. International journal of sport nutrition and exercise metabolism. 2004;14(3):298-307.

    26. Anghelescu I-G, Edwards D, Seifritz E, Kasper S. Stress management and the role of Rhodiola rosea: a review. International Journal of Psychiatry in Clinical Practice. 2018:1-11.

    27. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nordic Journal of Psychiatry. 2007;61(5):343-8.

    28. Mao JJ, Li QS, Soeller I, Xie SX, Amsterdam JD. Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial. Journal of clinical trials. 2014;4:170-.

    29. van Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann K. Monoamine oxidase inhibition by Rhodiola rosea L. roots. Journal of ethnopharmacology. 2009;122(2):397-401.

    30. Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. 2015;29(12):1934-9.

    31. Jówko E, Sadowski J, Długołęcka B, Gierczuk D, Opaszowski B, Cieśliński I. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of sport and health science. 2018;7(4):473-80.

    32. Ishaque S, Shamseer L, Bukutu C, Vohra S. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC complementary and alternative medicine. 2012;12:70-.

    33. Lee Y, Jung J-C, Jang S, Kim J, Ali Z, Khan IA, et al. Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea. Evidence-based complementary and alternative medicine : eCAM. 2013;2013:514049-.

    34. Bucci LR. Selected herbals and human exercise performance. The American Journal of Clinical Nutrition. 2000;72(2):624S-36S.

    35. Challinor VL, Parsons PG, Chap S, White EF, Blanchfield JT, Lehmann RP, et al. Steroidal saponins from the roots of Smilax sp.: Structure and bioactivity. Steroids. 2012;77(5):504-11.

    36. Lim PHC. Asian herbals and aphrodisiacs used for managing ED. Translational andrology and urology. 2017;6(2):167-75.

    37. Rogerson S, Riches CJ, Jennings C, Weatherby RP, Meir RA, Marshall-Gradisnik SM. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. Journal of strength and conditioning research. 2007;21(2):348-53.

    38. Kamenov Z, Fileva S, Kalinov K, Jannini EA. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction—A prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas. 2017;99:20-6.

    39. Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction – an evaluation using primates, rabbit and rat. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;15(1):44-54.

    40. Roaiah MF, El Khayat YI, GamalEl Din SF, Abd El Salam MA. Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM). Journal of sex & marital therapy. 2016;42(4):297-301.

    41. Qureshi A, Naughton DP, Petroczi A. A Systematic Review on the Herbal Extract Tribulus terrestris and the Roots of its Putative Aphrodisiac and Performance Enhancing Effect. Journal of Dietary Supplements. 2014;11(1):64-79.

    42. Ajarem JS. Effects of fresh kola-nut extract (Cola nitida) on the locomotor activities of male mice. Acta physiologica et pharmacologica Bulgarica. 1990;16(4):10-5.

    43. Oboh G, Nwokocha KE, Akinyemi AJ, Ademiluyi AO. Inhibitory effect of polyphenolic-rich extract from Cola nitida (Kolanut) seed on key enzyme linked to type 2 diabetes and Fe(2+) induced lipid peroxidation in rat pancreas in vitro. Asian Pacific journal of tropical biomedicine. 2014;4(Suppl 1):S405-S12.

    44. Solipuram R, Koppula S, Hurst A, Harris K, Naragoni S, Fontenot K, et al. Molecular and biochemical effects of a kola nut extract on androgen receptor-mediated pathways. Journal of toxicology. 2009;2009:530279-.

    45. Zajac A, Poprzecki S, Maszczyk A, Czuba M, Michalczyk M, Zydek G. The effects of a ketogenic diet on exercise metabolism and physical performance in off-road cyclists. Nutrients. 2014;6(7):2493-508.

  • salicylate food list

    Salicylate sensitivity, also known as salicylate intolerance, is any adverse effect that occurs when a usual amount of salicylate is ingested. People with salicylate intolerance are unable to consume a normal amount of salicylate without adverse effects. 

  • Burning Plastics

    Burning plastic releases carbon monoxide, dioxins & furans the most toxic chemicals known to science, remove microplastics from your tap water and stop buying plastic bottles immediately. Remove microplastics with an  Eco Gravity Water Filter.

  • Heart Traditional Chinese Medicine

    In TCM summer corresponds to the heart. According to Chinese medicine, now is the time to focus on the heart & incorporate foods & lifestyle advice that will tonify heart.

  • Traditional Chinese Medicine the Eyes

    In Traditional Chinese Medicine, in order to treat the eyes, one must treat the liver. Dietary, lifestyle, supplement & herbal medicine advice that can be prescribed to improve nutrient blood flow to the eyes to improve eye health & function.

  • Weight Loss Tonic

Eco Water Filters

Environmentally Friendly, Clean, Healthy & Plastic Free Water

Herbal Tonics

Practitioner Strength Organic or Wildcrafted Herbal Extracts

Consultations

Diagnose, Assess & Treat Physical, Mental & Emotional Disorders